Structure of the DPS-Like Protein fromSulfolobus solfataricusReveals a Bacterioferritin-Like Dimetal Binding Site within a DPS-Like Dodecameric Assembly†,‡
نویسندگان
چکیده
منابع مشابه
orf4 of the Bacillus cereus sigB gene cluster encodes a general stress-inducible Dps-like bacterioferritin.
The function of orf4 in the sigB cluster in Bacillus cereus ATCC 14579 remains to be explored. Amino-acid sequence analysis has revealed that Orf4 is homologous with bacterioferritins and Dps. In this study, we generated an orf4-null mutant and produced recombinant protein rOrf4 to establish the role of orf4. In vitro, the purified rOrf4 was found to exist in two distinct forms, a dimeric form ...
متن کاملAn archaeal antioxidant: characterization of a Dps-like protein from Sulfolobus solfataricus.
Evolution of an oxygenic atmosphere required primordial life to accommodate the toxicity associated with reactive oxygen species. We have characterized an archaeal antioxidant from the hyperthermophilic acidophile Sulfolobus solfataricus. The amino acid sequence of this approximately 22-kDa protein shares little sequence similarity with proteins with known function. However, the protein shares ...
متن کاملThe Dps-like protein Fri of Listeria monocytogenes promotes stress tolerance and intracellular multiplication in macrophage-like cells.
Members of the ferritin-like Dps protein family are found in a number of bacterial species, where they demonstrate the potential to bind iron, and have been implicated in tolerance to oxidative stress. In this study of the food-borne pathogen Listeria monocytogenes, the fri gene encoding a Dps homologue was deleted, and, compared to wild-type cells, it was found that the resulting mutant was le...
متن کاملOn the Structure of Metric-like Spaces
The main purpose of this paper is to introduce several concepts of the metric-like spaces. For instance, we define concepts such as equal-like points, cluster points and completely separate points. Furthermore, this paper is an attempt to present compatibility definitions for the distance between a point and a subset of a metric-like space and also for the distance between two subsets of a metr...
متن کاملCoevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis
A protein named AAH was isolated from the bacterium Microbacterium arborescens SE14, a gut commensal of the lepidopteran larvae. It showed not only a high sequence similarity to Dps-like proteins (DNA-binding proteins from starved cell) but also reversible hydrolase activity. A comparative genomic analysis was performed to gain more insights into its evolution. The GC profile of the aah gene in...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2006
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi060782u